Autore del contributo di commento:
Giuseppe Sito - Membro Comitato Scientifico Agorà
ARTICOLO ORGINALE OGGETTO DEL COMMENTO
September 2016 - Volume 42 - Issue 9 - p 1094–1101
Repeated OnabotulinumtoxinA Treatment of Glabellar Lines at Rest Ov er Three Treatment Cycles
Carruthers, Alastair MD; Carruthers, Jean MD; Fagien, Steven MD; Lei, Xiaofang PhD; Kolodziejczyk, Julia PhD; Brin, Mitchell F. MD
BACKGROUND: OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellarlines at rest; however, less is known regarding the effect of repeat treatment on more severe lines at rest.
OBJECTIVE: To assess the effect of repeated onabotulinumtoxinA treatment for reduction of glabellar lines at rest.
METHODS: Subjects 18 to 75 years old with at least mild glabellar lines at rest, as assessed by the validated Facial Wrinkle Scale (FWS) with photonumeric guide (score ≥ 1), received 3 treatments of 20 U onabotulinumtoxinA 4 months apart (N = 225). “Response” was defined as elimination of glabellar lines at rest (FWS score = 0) at any time point (Days 7, 30, 60, 90, and 120). Effect of treatment cycle on response was analyzed using repeatedmeasures logistic regressions (p < .05).
RESULTS: Most subjects were female (85%) and white (88%) (age range: 35–54 years). The likelihood of significant response was as follows: for all subjects combined (odds ratio [OR]: 1.31), for subjects with mild resting lines at baseline (OR: 1.49), and for older women (≥55 years) with mild resting lines at baseline (OR: 2.22). Of all subjects, 76% responded after 1 treatment, and 45% responded in all 3 cycles.
CONCLUSION: Subjects repeatedly treated with onabotulinumtoxinA showed progressive improvement in glabellar lines at rest.
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