AGORÀ UP TO DATE 2026: Scientific update and new perspectives in aesthetic medicine

On April 11, 2026, at Monterosa 91 in Milan, Agorà Up To Date 2026 took place—a full day dedicated to scientific updating, bringing together professionals to discuss the latest developments in aesthetic medicine.

The event clearly highlighted the increasingly multidisciplinary nature of the field, now built on the integration of regenerative medicine, injectables, dermocosmetics, energy-based technologies, lasers, and medical gases, within a highly personalized and evidence-based approach.

CLINICAL INNOVATION: NEW CHALLENGES AND A MULTIMODAL APPROACH

Among the most relevant topics, particular attention was given to the phenomenon of “Ozempic face,” associated with the use of GLP-1 receptor agonists. Rapid weight loss is linked to a reduction in facial fat volume and an acceleration of aging signs, making a multimodal therapeutic approach essential.

In this context, aesthetic treatments are evolving toward integrated protocols combining fillers, botulinum toxin, biostimulation, and advanced technologies, with increasing focus on treatment timing and prevention of aesthetic deterioration.

BOTULINUM TOXIN: A FUNCTIONAL AND INTERACTIVE APPROACH

Botulinum toxin was the focus of a highly engaging interactive session, involving participants in the analysis of a complex clinical case of post-facial paralysis asymmetry.

Through photographic documentation and anatomical references, participants were able to collaboratively identify the muscles involved and discuss potential treatment strategies, supported by real-time interactive voting. Additional clinical cases demonstrated how scientific evidence can be translated into daily practice, with particular attention to anatomical variations, functional outcomes, and muscle modulation strategies.

REGENERATIVE MEDICINE: POTENTIAL AND LIMITATIONS

Significant attention was also given to regenerative aesthetic medicine, described as a rapidly evolving field still characterized by a degree of heterogeneity.

Available treatment options—including PRP, polynucleotides, exosomes, and biomaterials—share common biological mechanisms such as fibroblast stimulation and collagen production, but still require standardization and robust clinical evidence for full integration into routine practice.

TECHNOLOGIES: LASERS, ENERGY-BASED DEVICES, AND MEDICAL GASES

A central role was attributed to laser and energy-based technologies, which are increasingly integrated into treatment protocols for improving skin quality and stimulating collagen production.

Alongside these, the role of medical gases was also explored as an emerging field, with applications related to microcirculation improvement, tissue oxygenation, and regenerative processes. In both areas, the importance of informed and responsible use, supported by strong technical and scientific knowledge, was emphasized.

SAFETY AND COMPLICATIONS: TOWARD SHARED PROTOCOLS

Safety was a key theme throughout the entire event, with particular focus on complication management, also addressed within the framework of shared recommendations developed in collaboration with the SIME.

In the context of rhinofiller procedures, it was emphasized that despite the low incidence of severe adverse events, vascular risks require specific expertise and careful prevention. Similarly, the complexity of certain anatomical areas—such as the mandibular region—was highlighted, where delayed complications demand a structured diagnostic and therapeutic approach.

ULTRASOUND: AN INCREASINGLY ESSENTIAL TOOL

Another key aspect that emerged during the day was the growing importance of ultrasound in aesthetic medicine.

No longer limited to diagnostics, ultrasound is now widely used as a procedural guide and as a tool in complication management, significantly improving treatment precision, safety, and predictability.

DERMOCOSMETICS: INTEGRATION INTO THE TREATMENT PATHWAY

Finally, the role of dermocosmetics was emphasized as an integral part of the therapeutic pathway.

No longer just a complementary element, it is now considered a true clinical tool, capable of improving skin barrier function, supporting treatments, and optimizing recovery times, particularly when combined with technological procedures.

Overall, Agorà UP TO DATE 2026 outlined a vision of aesthetic medicine that is increasingly integrated, scientific, and personalized, where innovation and safety go hand in hand.

The aesthetic physician is increasingly positioned as a central figure, responsible for managing clinical complexity through multidisciplinary expertise and a critical, informed, and evidence-based approach.