Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice
- Francesca Arrigoni
- 1 day ago
- 1 min read
The increasingly widespread use of hyaluronic acid–based fillers has led to growing interest in the prevention and management of complications associated with these procedures, which may range from minor aesthetic irregularities to potentially severe vascular events.
In this context, a recent review published in the Journal of Clinical Medicine provides an updated and systematic analysis of the role of hyaluronidase in contemporary aesthetic medicine.
The article explores the main characteristics of the different hyaluronidase formulations currently available, comparing their origin, enzymatic activity, and safety profiles. One of the central issues in clinical practice is critically discussed: the wide variability of dosing and administration protocols, largely related to the lack of universally shared guidelines.
Particular attention is devoted to safety aspects. Although hyaluronidase is generally considered an effective and well-tolerated drug, it is not without potential risks, including allergic reactions and local adverse effects. The authors therefore emphasize the importance of appropriate medical history assessment and informed use of the enzyme in clinical practice.
Extensive discussion is dedicated to the management of filler-related vascular complications, an area in which hyaluronidase remains a fundamental therapeutic tool. Prompt intervention, detailed knowledge of vascular anatomy, and immediate availability of the enzyme are identified as key factors in improving prognosis and reducing the risk of permanent sequelae.
Overall, the review offers a clear and up-to-date overview of the use of hyaluronidase in aesthetic medicine, highlighting the need for continuous education and increased clinical awareness as essential elements for safe and responsible practice.
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